PHYSICAL EXERCISE AND FITNESS :
MEDICAL CONDITIONS: OBESITY:
Exercising Tough for Overweight People Due to Chemical Imbalance: Research
Exercising Tough for Overweight People Due to Chemical Imbalance:
Submitted by Diana Bretting on
Saturday 12/31/2016 – 10:46
A shorter URL for the above link:
Exercising and regular physical activity are considered among the top ways to shed extra weight but physical activity is usually found low among people in overweight and obese categories. A new research conducted by researchers at the National Institutes for Health (NIH) has suggested that a chemical imbalance in brain makes is really difficult for overweight individuals to raise their level of physical activity or exercise. The research team found that diet-induced obesity leads to changes in functioning of brain. People in this category might have a higher tendency to move less compared to people who have ideal weight.
The NIH study was conducted on lab mice. The research team found that obesity leads to changes in dopamine. Dopamine is brain chemical which impacts our mood, motor control and appetite. Many people make New Year resolutions to shed extra weight. And, research has suggested that most of the resolution related to weight control or higher physical activity are broken within first couple of weeks of New Year. NIH study team found changes in brains of overweight mice. Overweight mice became couch potatoes. The research team controlled the DR2 receptor using a drug, to control impact on lean and overweight mice.
The study has been published in journal Cell Metabolism. Sedentary lifestyle has been blamed in combination with high calorie, high sugar diet for obesity issues in United States and many other countries.
The complete article may be read at the URL above.
Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity
Danielle M. Friend9, Kavya Devarakonda9, Timothy J. O’Neal9, Miguel Skirzewski, Ioannis Papazoglou, Alanna R. Kaplan, Jeih-San Liow, Juen Guo, Sushil G. Rane, Marcelo Rubinstein, Veronica A. Alvarez, Kevin D. Hall, Alexxai V. Kravitz10,correspondencePress enter key for correspondence informationemailPress enter key to Email the author
Publication stage: In Press Corrected Proof
Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling contribute to physical inactivity in obesity. To investigate this, we quantified multiple aspects of dopamine signaling in lean and obese mice. We found that D2-type receptor (D2R) binding in the striatum, but not D1-type receptor binding or dopamine levels, was reduced in obese mice. Genetically removing D2Rs from striatal medium spiny neurons was sufficient to reduce motor activity in lean mice, whereas restoring Gi signaling in these neurons increased activity in obese mice. Surprisingly, although mice with low D2Rs were less active, they were not more vulnerable to diet-induced weight gain than control mice. We conclude that deficits in striatal D2R signaling contribute to physical inactivity in obesity, but inactivity is more a consequence than a cause of obesity.
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